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jak2 stat3 inhibitor ag490  (MedChemExpress)
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MedChemExpress jak2 stat3 inhibitor ag490
Jak2 Stat3 Inhibitor Ag490, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ag490  (Santa Cruz Biotechnology)
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Inhibition of STAT3 enhances MeHg-induced Nrf2 activity in mouse hypothalamic neuronal GT1-7 cells. A Representative western blot analysis of Nrf2 protein levels in cytoplasmic and nuclear fractions, with densitometry quantification of nuclear Nrf2 protein levels in GT1-7 cells pre-treated with 100 µM <t>AG490</t> or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 9 independent cell culture preparations). B qPCR analysis of Nfe2l2 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). C qPCR analysis of Keap1 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). D qPCR analysis of Slc7a11 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). E qPCR analysis of Nqo1 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). F qPCR analysis of Nfe2l2 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations).) qPCR analysis of Keap1 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). H qPCR analysis of Slc7a11 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 6–7 independent cell culture preparations). I qPCR analysis of Nqo1 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). Data are expressed as mean ± SD. * indicates p < 0.05
Ag490, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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jak2 inhibitor ag490  (MedChemExpress)
97
MedChemExpress jak2 inhibitor ag490
Inhibition of STAT3 enhances MeHg-induced Nrf2 activity in mouse hypothalamic neuronal GT1-7 cells. A Representative western blot analysis of Nrf2 protein levels in cytoplasmic and nuclear fractions, with densitometry quantification of nuclear Nrf2 protein levels in GT1-7 cells pre-treated with 100 µM <t>AG490</t> or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 9 independent cell culture preparations). B qPCR analysis of Nfe2l2 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). C qPCR analysis of Keap1 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). D qPCR analysis of Slc7a11 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). E qPCR analysis of Nqo1 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). F qPCR analysis of Nfe2l2 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations).) qPCR analysis of Keap1 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). H qPCR analysis of Slc7a11 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 6–7 independent cell culture preparations). I qPCR analysis of Nqo1 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). Data are expressed as mean ± SD. * indicates p < 0.05
Jak2 Inhibitor Ag490, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ag490/AG490/10__1007_slash_s42995___026___00415___z-101-36-39
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jak2 inhibitor ag490 - by Bioz Stars, 2026-11
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ag490  (MedChemExpress)
97
MedChemExpress ag490
Inhibition of STAT3 enhances MeHg-induced Nrf2 activity in mouse hypothalamic neuronal GT1-7 cells. A Representative western blot analysis of Nrf2 protein levels in cytoplasmic and nuclear fractions, with densitometry quantification of nuclear Nrf2 protein levels in GT1-7 cells pre-treated with 100 µM <t>AG490</t> or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 9 independent cell culture preparations). B qPCR analysis of Nfe2l2 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). C qPCR analysis of Keap1 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). D qPCR analysis of Slc7a11 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). E qPCR analysis of Nqo1 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). F qPCR analysis of Nfe2l2 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations).) qPCR analysis of Keap1 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). H qPCR analysis of Slc7a11 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 6–7 independent cell culture preparations). I qPCR analysis of Nqo1 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). Data are expressed as mean ± SD. * indicates p < 0.05
Ag490, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ag490/AG490/pm42462475-65-0-17
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chemical inhibitors ag490  (MedChemExpress)
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MedChemExpress chemical inhibitors ag490
Inhibition of STAT3 enhances MeHg-induced Nrf2 activity in mouse hypothalamic neuronal GT1-7 cells. A Representative western blot analysis of Nrf2 protein levels in cytoplasmic and nuclear fractions, with densitometry quantification of nuclear Nrf2 protein levels in GT1-7 cells pre-treated with 100 µM <t>AG490</t> or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 9 independent cell culture preparations). B qPCR analysis of Nfe2l2 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). C qPCR analysis of Keap1 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). D qPCR analysis of Slc7a11 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). E qPCR analysis of Nqo1 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). F qPCR analysis of Nfe2l2 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations).) qPCR analysis of Keap1 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). H qPCR analysis of Slc7a11 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 6–7 independent cell culture preparations). I qPCR analysis of Nqo1 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). Data are expressed as mean ± SD. * indicates p < 0.05
Chemical Inhibitors Ag490, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ag490/AG490/pm42032729-43-0-9
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Inhibition of STAT3 enhances MeHg-induced Nrf2 activity in mouse hypothalamic neuronal GT1-7 cells. A Representative western blot analysis of Nrf2 protein levels in cytoplasmic and nuclear fractions, with densitometry quantification of nuclear Nrf2 protein levels in GT1-7 cells pre-treated with 100 µM AG490 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 9 independent cell culture preparations). B qPCR analysis of Nfe2l2 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). C qPCR analysis of Keap1 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). D qPCR analysis of Slc7a11 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). E qPCR analysis of Nqo1 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). F qPCR analysis of Nfe2l2 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations).) qPCR analysis of Keap1 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). H qPCR analysis of Slc7a11 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 6–7 independent cell culture preparations). I qPCR analysis of Nqo1 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). Data are expressed as mean ± SD. * indicates p < 0.05

Journal: Neurochemical Research

Article Title: Nrf2 and STAT3 Pathways in Protecting Against Methylmercury-Induced Oxidative Stress in Hypothalamic Neuronal GT1-7 Cells

doi: 10.1007/s11064-026-04898-1

Figure Lengend Snippet: Inhibition of STAT3 enhances MeHg-induced Nrf2 activity in mouse hypothalamic neuronal GT1-7 cells. A Representative western blot analysis of Nrf2 protein levels in cytoplasmic and nuclear fractions, with densitometry quantification of nuclear Nrf2 protein levels in GT1-7 cells pre-treated with 100 µM AG490 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 9 independent cell culture preparations). B qPCR analysis of Nfe2l2 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). C qPCR analysis of Keap1 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). D qPCR analysis of Slc7a11 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). E qPCR analysis of Nqo1 mRNA levels in GT1-7 cells treated with 10 or 100 µM AG490 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). F qPCR analysis of Nfe2l2 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations).) qPCR analysis of Keap1 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). H qPCR analysis of Slc7a11 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 6–7 independent cell culture preparations). I qPCR analysis of Nqo1 mRNA levels in GT1-7 cells treated with 15 or 30 µM C188-9 for 1 h, followed by co-exposure to 5 µM MeHg for 6 h ( n = 7 independent cell culture preparations). Data are expressed as mean ± SD. * indicates p < 0.05

Article Snippet: To investigate the role of STAT3 in Nrf2 induction, cells were pre-treated for 1 h with either 10 or 100 μM AG490 (Tyrphostin B42, Santa Cruz Biotechnology, Santa Cruz biotechnology, Inc. cat. no. sc-202046) or with 15 or 30 μM of STAT3 Inhibitor XIII, C188-9 (CalbioChem, cat. no. 573128).

Techniques: Inhibition, Activity Assay, Western Blot, Analysis, Cell Culture